In Parkinson’s Disease, Blocking LRRK2 Activity Is Not A Simple Answer

<p>Main Category: Parkinsons Disease
Also Included In: Genetics;  Anxiety / Stress
Article Date: 30 May 2012 1:00 PDT</p>

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<p>Mutations in a LRRK2 gene are a many common means of genetic Parkinsons illness (PD). New examine published in BioMed Centrals open entrance biography Molecular Neurodegeneration demonstrates that detriment of duty of LRRK2 (by deletion of a kinase domain) leads to changes in engine co-ordination and causes anxiety-like behaviors and kidney lapse in mice though inspiring dopamine-mediated mind activity.</p>

<p>The protein LRRK2 is concerned in controlling a structure and duty of neurons. Aberrant LRRK2 has been shown experimentally to have pointed effects on dopamine signaling that might counterpart a beginning changes in PD patients. In sequence to examine how LRRK2 works r...